We are committed that researchers and clinicians working on large scale genome sequencing projects can apply methods that allow for the most complete and scientifically rigorous results in both research and clinical applications.
The BioGraph Engine by Spiral Genetics is specifically designed to address the issues associated with large scale genome sequencing projects using Illumina next generation whole genome sequencing data.
The BioGraph Engine preprocesses the data to produce an analysis format that allows for rapid assembly of reads and search by sequence. This results in the following benefits:
A. Call structural variants (genetic changes over 50 base pairs in length) by assembling reads with a high sensitivity and with accurate nucleotide sequence.
B. Create a dynamic graph reference of variation in a population, including structural variation. This allows for sequencing projects to capture variation across a population or study while using short read sequencing data.
C. Rapidly genotype for variants in a dynamic graph reference. This allows for recovery of variants discovered using other methods, including long read sequencing. These methods assist in achieving the maximum utility of short reads. This is also an important step in being able to capture and understand variation in populations around the world.
D. The python SDK can be used to create your own queries using reference location, searching for a specific sequence in any read in the sample or assembling reads to address specific questions.
The structure of the data also assists in reducing computational and storage costs.